Hyderabad: Covid-19 appears because perhaps the first pandemic in human history for treatment of more than 200 drug compounds has been tested and around 70 therapeutic agents so far.
A study study involving scientists, including those from the National Institute of Pharmaceutical Education and Research (Niper), Hyderabad, found that as many as 265 clinical trials were carried out to find care suitable for viruses and they have been shown to have a direct effect on reducing viral load and manage disease.
Interestingly, except for vaccines, all drugs tested so far are old drugs and returned for Covid-19 with various levels of success.
“The acute development of Covid-19 and the level of high infection raises a major challenge for therapeutic management and critical care.
The structure of the virus, genome (complete genetic information) and proteome (complete protein information) has been described which produces a signal to target the available therapeutic entities.
More Of 200 compounds have been played and 69 therapeutic agents are undergoing clinical trials around the world, “said this study.
The study said a number of anti-parasitic and anti-viral drugs, monoclonal antibodies, vaccines and stem cell therapy were tried as part of a well-designed clinical trial.
Apart from vitamin C, vitamin D supplementation has been found useful in reducing risk.
It was found that vitamin D lowered the level of viral replication and controlled the production of pro-inflammatory cytokines responsible for lung injury.
Vitamin D supplementation can also manage the risk of influenza.
This research was published in the recent edition of the biomedicine & pharmacotherapy scientific journal.
Apart from Niper, Hyderabad, researchers from the Biomedical Research Center, Delhi University, and College of Pharmacy, Mohali, are also part of this study.
The team consists of Mukesh Kumar, Jitender Madan, Rupinder Kaur Sodhi, Shashi Bala Singh and Anju Katyal.
“Covid-19 has forced human civilization to think, innovate, develop and prioritize all possible strategies to fight infection.
The combination of drugs tested has shown uniform results in affected patients.
Therefore, the need to extend the drug repertoire or Additional therapeutics to deal with Covid-19 are guaranteed, “advice the researchers.
According to research, antimalarial drugs such as chloroquine diphosphate and hydroxychloroquine, anti-viral drugs such as Ritonavir and Lopinavir, Interferon (recombinant), Favipiravir, Baloxavir, Darunavir, Ganovo, Asc09 / Ritonavir, Arbidol Hydrochloride, Carrimycin and Triazavirin, corticosteroids such as methylprednisolone stem cells Involving mesenchymal stem cells from the cord, blood plasma from the navel cord, blood mononuclear cells and immunomodulators such as plasma recovery, and monoclonal antibodies such as toclillizumab, adalimumab, Ixekizumab and Camrelizumab are tested.
The doctor also tested medicines such as remedies and heparin.