Pune: The level of high protection (seroprevalence) against Covid-19 has been detected in more than 500 health service workers and even 3-7 months after taking two covishield doses, a latest analysis by Pune BJ Medical College (BJMC) and Sassoon Hospital has revealed.
With a high level of protection (seroprevalence) in participants at this time, this study concluded that the third amplifier, while a piece of population had not yet received their second shot, may not be recommended, Dr.
Muralidhar Tambe, Professor and Head of Community Medicine at BJMC, told TII.
The study also found that in all 558 health workers (HCWS), which is part of the study, the prevalence of antibodies above 90% month after completing two covid vaccine doses.
Dr.
Tambe said, “Although we found that the prevalence of antibodies decreased because the duration of the interval increased after two covid vaccine doses, the level of immunity remained high.
The positivity of antibodies among the research participants was at 96.77% in three months posting full vaccination, up to 100 % at four months, and then fell to 91.89% on seven months after two initial doses.
“He said except for five individuals, who had received Covaxin, all other study participants had received covishield.
Dr.
Tambe said overall, from 558 HCW participating in this study, 94.4% positive for Covid neutralized antibodies during the study period.
“At the time of the study, some HCW had completed three months, while some had completed 4-7 months after two doses of covid vaccination.
In the next aspect of the study, we analyzed antibody paper in their serum according to the duration of the period of time competed after full vaccination.
Blood samples were collected two months ago, “he said.
Dr.
Rajesh Karyakarte, Head, Department of Microbiology, BJMC, said, “The competitive Elisa kit is used to detect the antibody that is present in the serum.
In accordance with the method, if anti-covid-19 antibodies the patient’s serum causes more than 50% signal inhibition, then the serum considered effective neutralization activity against SARS-COV-2.
said, “In addition to the immunity provided by the vaccine, many individuals may have obtained hybrid immunity due to sub-clinical infections.” Dr.
Vinayak Kale, Dean at BJMC, said this research will be further extended by three months to find out whether the booster dose must be recommended on individuals who have competed nine months or more after two initial doses.
Dr.
Sanjay Pujari from the ICMR National Task Force in clinical research for Covid-19 and the Director of the Institute of Infectious Disease, Pune, “Today’s semi quantitative antibody test is not recommended to assess immunity after immunity.
Protection is still unclear.
Even to neutralize the antibody titers cut off Right outside the absolute protection achieved is unclear.
“The findings of studies assume their significance is mainly after the emergence of Omicron, which has been attended by increasing pressure on the United Government to recommend a booster dose for people who take six to seven-seven covid vaccine shots.
Dr.
Kale, Dr.
Suvarna Joshi and Dr.
Nandkumar Salunge are other researchers from BJMC involved in the analysis.
“Antibodies formed after covid vaccination can be proven in the blood and began to decrease after a few months of vaccination.
It has not been clearly examined for the duration of what is stored by antibodies at satisfactory levels in the blood.
This has been postulated in the past that their level began to fall after Three months of post-vaccination.
It has also been said that after six months, the level of antibodies might even go down to the protective level, leaving individuals who are susceptible to Covid, “said Dr.
Vinayak Kale, Dean of BJMC