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Breakthrough infection produces strong immunity to Covid-19 variants: Study

WASHINGTON: Infected people after vaccinated in developing immune responses that greatly increased against the Virus variant of the SARS-COV-2 which caused Covid-19, according to a laboratory study.
This study, published in the Journal of the American Medical Association (JAMA), showed that the breakthrough of infection produced a strong immune response to the Delta variant.
The findings show that the immune response to such people tends to be very effective against other variants because the SARS-COV-2 virus continues to mutate.
“You can’t get a better immune response than this.
This vaccine is very effective against severe diseases,” said Senior writer Fikadu Tafesse, a professor assistant at Oregon Health & Science University (OHSU) in the US.
“Our study shows that individuals are vaccinated and then exposed to breakthrough infections have super immunity,” Tafesse said.
The study found that antibodies measured in blood samples from a breakthrough case were both more abundant and far more effective – as many as 1,000 percent – compared to the antibodies produced two weeks after the second dose of the Pfizer vaccine.
The results show every explanation after vaccination actually serves to strengthen the immune response to the next exposure even for a new variant of the virus.
“I think this talks with the final game that is finally.
That does not mean we are at the end of the pandemic, but it refers to where we tend to land,” said the study of co-author Marcel Curlin, a professor in Ohsu Medical School.
“Once you are vaccinated and then getting a virus, you might be protected well from the future variant,” Curlin said.
This study implies that long-term results will be a tapering-off of the severity of the epidemic throughout the world, the researchers said.
Immunity vaccines, they said, are currently undergoing a real world test against the new Omicron variant.
“We have not examined the Omicron variant specifically, but based on the results of this study we will anticipate that the breakthrough of the infection of the Omicron variant will result in an immune response which is equally strong among people who are vaccinated,” Tafesse said.
This study compares blood samples collected from a total of 52 people, all OHSU employees are vaccinated with the Pfizer vaccine and then registered in this study.
26 people were identified through testing having light breakthrough infections after vaccination.
Among cases of breakthroughs confirmed sequentially, 10 involves a highly contagious Delta variant, nine non-Delta and seven are unknown variants.
The researchers then measured the immune response to the life virus exposed to the blood of the samples from people with a breakthrough case and compare it with the immune response to the control group.
They found a breakthrough case producing more antibodies at the beginning, and the antibodies were substantially better in neutralizing living viruses.
This study underlines the fact that vaccination remains the key to ending the pandemic.
“The key is to get vaccination.
You must have a protection foundation,” Curlin added.

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