Pune: The good bacteria in the nose environment of the Covid-19 positive person can affect the severity of infection, a study by the National Cell Science (NCCS) National Center (NCCS) and BR Medical College has revealed.
Scientists say this can also explain why certain individuals infected with SARS-COV-2 asymptomatic – a rather concept like the existence of good bacteria in the intestine, which helps one’s immunity against infection.
The study also observes the abundance of higher-specific opportunistic pathogens in those infected with Covid-19, indicating that the inflammatory environment caused by infection leads to increased bacterial pathogens that can cause secondary infections.
Secondary infections can occur when infections are different, known as primary infections, making someone more susceptible to disease.
“Increased pathogenic bacteria in nasal microbiomes (microorganisms in certain environments) Covid-19 patients are caused by mucus accumulated, which is known to support the growth of these organisms, and the hyper-inflammatory environment (broad inflammation in the body) that supports their growth,” Avinash Sharma said, Scientists, NCCS, who lead research.
Sharma told TOI that the increase in various opportunistic pathoging in the nose environment could also also promote the entry of viruses through routes.
He said, “There is a reduction in good bacteria, which is known to have a positive impact on the immune system, in the nose area of ​​Covid-19 patients.
This in turn causes opportunistic pathogens to colonize the site.
This research is important because it can help determine how the virus actually promotes improvement Opportunistic pathogens, which can increase the severity of other diseases.
“As part of this study, the researchers collected nasopharyngeals from patients suspected of being clinically SARS-COV-2 infection and their family’s contact.
Sharma said it was interesting to investigate the shift in microbiomas in individuals infected with SARS-COV-2 asymptomatic and symptomatic.
“Many specific bacteria increase in the nose environment of SARS-COV-2 symptomatic patients compared to those who are not infected.
Symptomatic and asymptomatic individuals are classified further based on their age and gender groups.
We also find changes in contrast to the abundance of microorganisms in individuals without symptoms and SIMTomatic in all age groups.
The differences in existing microbiomes can also affect the severity of Covid in patients, even though this needs further research, “Sharma said.
The study has found that in many cases, the abundance of ‘streptococcus’ (harmful bacteria) increases, while beneficial bacteria such as Villonella, Rothia, and Prevotella 7 decreases in infected individuals.
Dr.
Kaushal Sheth, Honorary Secretary of the Indian Otolaryngology Association, told TII, “the severity of the Covid-19 can be influenced by the existing commensal pathogens since this basically strengthens the mucosal barrier by reducing inflammatory reactions in the nasal mucosa layer, thus preventing the entry of the virus.” Sanjay Pujari from the Indian Council of the National Task Force Medical research on clinical research for Covid-19 and the Director of the Institute of Infectious Disease, Pune, to Toi, “This study made some interesting observations and made some interesting observations and made some interesting observations and made some interesting observations .
the first of its kind in India.
the findings on changes in nasal mikrobi covid patients tend to lead to further generation of hypotheses to be tested in a longitudinal study follow-up.
It will confirm the changes to the nasal Microbiome in various categories of patients covid for the disease.
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