Hyderabad: In the good news for couples without children, scientists from Hyderabad, Mangalore and Manipal have designed organic molecules that increase sperm functional competencies used for fertilizing in vitro (IVF).
MPTX small organic molecules have been developed by the eerappa rajakumara group from the biotechnology department, IIT Hyderabad; The Jagadeesh Prasad Dasappa group from Mangalore University; And Guruprasad Kalthur’s Group from the Kastba Medical College, Manipal Academy of Higher Education.
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The concentration is lower than the pharmacological agents that are widely used – pentoxifylline in IVF technology.
Compared to existing drugs, MPTX molecules are potentially better pharmacological agents for assisted reproductive technology.
Rajakumara Eerappa, Associate Professor, Biotechnology Department, IIT-H, said, “Our multi-institutional collaborative team will appear with formulations, using this MPTX combination and other molecules, which can be more effective than the existing formulation for.
IVF procedures.”
With an estimated 48 million infertile pairs worldwide, the reduction of sperm motility is one of the main causes of male infertility.
The motility is very important for sperm to reach fertilization places during natural conception.
In addition, the percentage of spermatzoa motile in ejaculation helps decide on the ideal artificial insemination method such as IVF for infertility treatment.
Pentoxifyline treatment increases sperm motility that struggles with unwanted premature acrosom reactions, which together determine the success of IVF.
The purpose of this DST-Serbian funded project is to increase the efficacy of pentoxifylline and reduce its country’s effects on sperm competencies and embryo development.
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Mahty, Director of Iit Hyderabad, said, “The excitement of parents cannot be defined in words.
The work led by Rajakumara Eerappa and his collaborators can bring happiness to be parents in an infertile pair, by increasing the success rate of IVF.
“IIT-H is one of its kinds of institutions to have a biomedical department and biotechnology separately maintain talent.
It also shows the power of synergistic collaboration.
I am sure that many technologies such as that significantly affect the community will continue to grow in continuous IIT-H.”
IIT Hyderabad Co-Designs Molecule to increase the success rate of IVF
