ROORKEE: Researchers at the Indian Institute of Technology Roorkee, led by Pranita P Sarangi, Department of Biosains and Bioengineering, IIT Roorkee, have shown a specific role of immune markers in the results of severe infections and sepsis.
This research, funded by a grant of biocare women’s scientists and an innovative biotechnology award grant from the Biotechnology Department, the Indonesian government has provided an important insight into the role of immune markers on sepsis related complications.
Neutrophils, monocytes and macrophages are white blood cells that act as dead cell scavengers and foreign objects such as bacteria and other pathogens.
They move from blood to the location of the infection to mop the foreign material that causes disease.
However, in an uncontrolled and severe infection, commonly called ‘sepsis’, there is abnormal activation and localization of these immune cells.
As a result, these cells form an ensemble, move around the body, and are stored in important organs such as lungs, kidneys, and liver, which can cause multi-organ failure or even death.
Safe! You have managed to throw your votelogin to see the results of research on research, Pranita P Sarangi, the Department of Biosains and BioEngineering, IIT ROCCEE, said, “Given the importance of monocytes, macrophages, and neutrophils in sepsis, it is important to understand the mechanism of the migration of the cells to detect Stages of inflammation and sepsis.
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When these immune cells move from blood vessels through the network space to reach an infected / inflamed site, they tie protein like collagen or fibronectin.
This binding occurs through a receptor molecule called Integrin on the cell surface.
Integrin receptors allow communication between immune cells and the surrounding matrix, which helps in cell migration and modulation of other functions.
However, their over-activity activities (called hyper-activation), can lead to problems.
In this study, Group Prof.
Sarangi uses two models of sepsis mouse to show the role of integrin in sepsis.
When there is an infection, the monocyte moves from blood circulation and bone marrow to an inflamed / inflamed network.
Once inside the tissue, this monocy is further mature into the macrophage and by feeling signals from the septic environment, these cells gradually move from their functions from inflammation to immunosuppressive subtypes that correlate with their integrin expression profiles.
“This finding will help detect the right stages of sepsis and treatment,” said the main researcher, “said the main researcher Mr.
Shiba Prasad Dash, who currently examines the PhD under the guidance of Prof.
Sarangi.
Talking about Prof.
research Ajit K Chaturvedi, Director of Iit Roorkee said “The work advances today’s understanding of sepsis biology and may help in the development of therapeutics of this life-threatening condition.”
The results of this study have been published in the Journal of Immunology, the Official Journal of the American Immunologists Association (AAA) and presented at an international conference organized by the Indian Immunology Society (Immunocon-2019).