Chennai: breast cancer may be immediately detected at the initial stage using a blood test, the results of clinical trials by the Cancer Institute in Adyar have shown.
If a larger clinical trial confirms this finding, this blood test may not only replace mammograms and physical examinations, but will also help in diagnosis and early care, improve results.
Blood tests look for three gene markers in cell-free DNA taken from women’s plasma, and identify all stages of cancer, including those at the initial stage when locked in a (non-invasive) channel, scientists said.
“In patients with breast cancer, there is a reduction in the expression of three protective genes called SostDC1, WIF1 and Dact2 because the mechanism is called the promoter methylation.
When the test ensures a substantial ‘methylation’ in the gene, it returns positive,” said Senior Scientist Dr.
Thangarajan Rajkumar, said who heads the Department of the Molecular Oncology of the Institute.
“In our study, all women test results with breast cancer returned positive.
Nine of 100 healthy people can be called positive, and they may need additional tests before negatively declared.
So, the sensitivity is 100% and the specificity is close to 91%,” he said.
The study was conducted in 218 women who suffered from various stages of breast cancer (including non-invasive), 240 healthy and other women with non-cancerous tumors.
The results of the study have been published in scientific journal reports.
“At least 16 women have initial stage cancer and this test also detects them.
This is a big advantage of this test,” Rajkumar said.
“The aim is to capture the tumor as early as possible ‘glasses expert says the survival of high-term survival to women if breast cancer is detected early.
For example, globally, the level of survival of women with local breast cancer is 99%.
But the possibility of survival Going down when the cancer has spread – 86% for those whose cancer has spread to lymph nodes and 27% if the tumor has metastasis with other organs.
“Our goal is to capture the tumor as early as possible,” said Amritha Sathyanaranyan, one of the scientists.
This disease advanced in more than 57% of women in India before being diagnosed.
“Women do not appear for mammograms or clinical examinations because they are shy or because they are afraid of diagnosis or due to lack of access to mammograms,” said Senior Surgical Oncologist Dr.
Sridevi V.
Breast Cancer is Cancer leading among women in the world.
In TN, breast cancer has followed the KANK Er cervical as the number one cancer among women.
The incidence rate adapted to the age of breast cancer in Chennai increased from 39.3 to 71.3 between 1985 and 2014.
This institution has submitted a patent and plans to conduct larger research including more patients with non-invasive cancer, for validation Furthermore.
“We are now looking for funds up to ₹ 35 lakh from generous and corporate for this,” said Rajkumar.