Hyderabad: A national joint study by researchers, including doctors from AIIMS, Mangalagiri (Vijayawada), has found that even though the new Covid-19 variant is alarming, Omicron, has a higher immune runaway rather than existing variants, there are no indications clearly increasing.
severity (affinity for acee2 binding) disease.
But it will be, the Delta variant is out of competence.
At present there is no clear evidence to increase virulence or deadly for Omicron.
“Omicron may have a larger ability to runaway the body than the existing concern variant (VOC) and Variant Interest (VOIS).
However, there is no clear indication of the analysis of predictive mutations that Omicron may have a higher virulence / deadly than other variants , including Delta.
Higher ability for immune escape may be the reason for recent surges in omicron cases, “said study based on computers (in silico analysis).
This research was published in the Preprint Online MEDRXIV server.
According to research, compared to the VOC list / Vois Omicron currently bear more variations in sequence, especially in protein surges and host receptor motifs.
Omicron shows the homology of nucleotide sequences and proteins closest to the Alfa variant for a complete sequence.
Mutations found mainly condensed in the Spike region (28 to 48) of viruses.
The team conducts correlation analysis of the relative proportion of the sequence of specific genomes (from October 1 to December 10), with current epidemiological data (new Covid cases and deaths) from South Africa to understand whether Omicron has an epidemiological advantage over other variants.
As many as 3,604 Omicron genomics from 54 countries were uploaded on GISAID until 10 December and the team had analyzed it for mutation characteristics.
Omicron shows more variations in sequences including protein spike receptor binder domains.