Categories: Varanasi

The findings of the ims-bhu to help understand Zika

Varanasi: Evan Because the Zika virus outbreak in Kanpur has increased the alarm, researchers in the molecular biology unit from the Institute of Medical Sciences, the University of Banaras Hindu (IMS-BHU) has reported important findings on the pathogenesis of the Zika virus, which, as they claim, will help In understanding the molecular pathogenesis of viruses and in the development of therapy.
“This study has been published in the journal Peer-Review of International ‘Molecular Neurobiology’ in September,” said Prof.
Sunit K.
Singh, Head of the Molecular Biology Unit, which is a famous molecular virology.
The research group contributed significantly in the field of molecular virology.
According to him, Zika Virus (ZikV) is a transmitted mosquito virus, transmitted by Aedes mosquitoes, the same mosquito which causes bloody virus infections, chikungunya and yellow fever.
The Zika virus can be transmitted from mothers to the fetus during pregnancy, which can cause microcephali (smaller than other heads) and other congenital malformations in infants, collectively referred to as the default Zika syndrome, while in adults, symptoms of mild fever.
, Headache, conjunctivitis, joint pain, and body rash.
Microcephaly leads to abnormal brain development.
Microcephali results may differ according to the level of brain damage.
He said that most people with Zika virus infection did not experience symptoms.
The incubation period of ZikV infection lasts for 2-7 days.
In 2015, a major zikv outbreak was reported in Brazil, North America, Pacific and Southeast Asia, infecting 1.5 million people and with more than 3,500 microcephali cases reported in infants.
In India, 157 positive zikv cases were reported in 2018.
At present, there is no definite antivirus against ZIKV and only the simtomatic treatment regime followed.
Zika virus infection is also a trigger for Guillain-barré syndrome, neuropathy and melitis, especially in adults and larger children.
The Zika virus vaccine is at various stages of current development.
According to him, the brain is surrounded by a barrier known as a blood-brain barrier (BBB), which separates the brain from the body’s peripheral blood circulation.
BBB is formed by the endothelial cells of the brain and these cells are put together by a protein named Protein intersection (TJS) and protein intersection of adherents (AJS).
If the expression of TJS and AJS protein is reduced, BBB is compromised and allows the movement of immune cells into the brain that causes damage to neurons.
ZikV infected cells issue viral proteins, NS1, which are directly related to the severity of the disease in patients.
His studies reported that the treatment of Zika Protein Virus NS1 compromised with BBB integrity and this could cause microcephaly and other brain-related disorders in infants.
The research group reported that the Zika Protein Virus NS1 increased the expression of Microrna-101_3p in microvascular microvascular cells of the human brain, which in turn suppressed the expression of intersection proteins and intersection of the intersection of adherents and which led to compromise in BBB integrity.
They reported that this could be one of several mechanisms responsible for compromise in blood brain barriers to facilitate the entry of the Zika virus in the brain.
“These findings will be very helpful in understanding the molecular pathogenesis of the Zika virus and in therapeutic development.
The diagnosis of Zika virus infection can be done with a blood laboratory test, urine and cement,” Singh said.

news2in

Share
Published by
news2in

Recent Posts

44 ordered to attack the procession

Ludhiana: The police have submitted FIR to four identified and at least 40 unknown attackers…

3 years ago

Punjab: Police Reject conspiracy theory in the case of Deep Sidhu

Sonīpat / Ludhiana / Ambala: Actor Punjabi - Activist Activist Deep Sidhu, who died in…

3 years ago

Punjab: Hidden Strength Working Behind PM Narendra Modi, Arvind Kejriwal, said Rahul Gandhi

PATIALA / MANSA / BARNALA: Attacking Prime Minister Narendra Modi and AAP National Convener Kejriawal,…

3 years ago

BJP made AAP to endanger the Congress, said Ajay

Jalandhar: BJP and AAM AAM AADMI parties are one party, Secretary General of the Ajay…

3 years ago

Our job is to make Punjab No. 1 State: Meenakshi Lekhi

Ludhiana: Minister of Union Culture Meenakshi Lekhi while campaigning to support the BJP candidate from…

3 years ago

Feb 20 is an opportunity to change the destiny of Punjab and his children: Bhagwant Mann

Machhiwara (Ludhiana): AAM AAM AADMI Party (AAP) Head of Punjab Candidate and Members of Parliament…

3 years ago