London: Throughout the pandemic, one important question has made scientists confused throughout the world: Why did some people get sick from Covid-19 while others did not show symptoms at all? Now, peering deep into the human genome by global initiatives with more than 3,000 researchers from 25 countries provide several answers.
There are 13 locations in the genome which is strongly related to vulnerability to viruses or severe cases, researchers report Thursday in journals that are nature.
The study began in March 2020 when scientists struggled to understand how the virus operated.
It culminated in the largest genome association study ever done, with researchers filtering genetic material from nearly 50,000 infected and two million people not infected.
The aim: Identification of human DNA pieces that correlate with people becomes very sick of the virus.
The results can help determine “some clear biological markers that can be used to reuse drugs or drugs in the pipeline,” said Mark Daly, a study writer who was the Director of the Institute for Molecular Medicine Finland at Helsinki University at the University of Helsinki At Helsinki University at Helsinki University at Helsinki University at Helsinki University at Helsinki University at Helsinki University at Helsinki University at Helsinki University at Helsinki University.
and a geneticist at Harvard University.
Natural reports summarize information from 46 studies and three meta-analyzes that investigate the role of human genetics in SARS-COV-2 infection and the severity of Covid-19.
Such studies are a bit similar to panning for gold.
We know our genetic makeup contributes to why some people are more susceptible to viral infections.
By filtering DNA from quite a lot of people, researchers hope to find Eureka’s moment explaining the reason.
Treating Covid patients with more efficient pain can also eliminate the pressure of the hospital system, send patient patients faster, especially in countries that are still struggling against significant outbreaks.
The results of genetic studies like this can offer drugstore drugs to develop new therapies besides identifying potential treatments that already exist on the market.
Some of the 13 significant genetic locations identified in previous studies have been associated with other diseases, including lung cancer and autoimmune diseases.
TYK2 Geneone Gene that looks very connected to the severity of the disease with Covid-19 is known as TYK2.
In healthy people, it helps control the body’s path for immune signaling and inflammatory signaling.
Previously, the TYK2 gene variant which was linked to by researchers to Covid-19 was found to be associated with a reduced risk of autoimmune disease but increased risk of TB.
The researchers suggested that since the previous variant had been shown to reduce gene function, the same mechanism could disrupt the body’s ability to effectively against Covid.
Other genes studies identified, FOXP4, associated with lung cancer.
The FoxP4 variant increases the expression of the gene, indicating that inhibiting genes may be a strategy for treating Covid.
Not every interesting genetic location identified by researchers have a clear link to explain its relationship with Covid.
A far more study will be needed to break down all the complexity between viruses and human DNA.
The diversity of the importance of genetic locations identified so far by researchers, two have a higher frequency among Asian ancestors than European ancestors, underlining how important genetic diversity.
Genetics has long offered the promise of personalized insight that could explain who was sick and how to treat them.
Pandemic only has an interest in that promise.
Last year, consumer genomic companies 23andme published research strengthens evidence that blood type can affect a person’s vulnerability to Covid-19 by seeing genes that influence blood type.