Connecticut: In a new study by Yale’s Akiko Iwasaki, the Immunobiology Professor Waldemar Von Zedtwitz, it was found that intranasal vaccination provides broad-based protection of heterologous respiratory viruses in mice.
This research has been published in the ‘Science Immunology Journal’.
“The best immune defense occurs at the gate, keeping the virus trying to enter,” Iwasaki said, senior research writer.
The mucous membrane contains their own immune defense system that combats air or food pathogens.
When challenged, this barrier network produces B cells which in turn issuing Immunoglobin A (IGA) antibodies.
Unlike vaccines that cause wealthy immune response systems, IGA antibodies work locally on the mucosal surface found in the nose, stomach and lungs.
While the role of the protective cell-producing cells has been established in fighting intestinal pathogens, Iwasaki laboratories wonder if triggering rib response can also produce a local immune response to the respiratory virus.
Working with researchers at the ACAHN School of Medicine on Mount Sinai in New York, they tested a protein-based vaccine designed to start the IGA immune response, giving it to mice through injections, as done by systemic immunization, and also intrasal.
They then expose mice to some influenza virus strains.
They found that mice who received intranasally vaccines were much better protected against respiratory influenza than those who received injections.
Nose vaccine, but not a shot, also the antibodies caused by protecting animals on various types of flu, not only to the vaccine strain intended to protect.
The Yale team is currently testing the nose vaccine strain against Covid strains on animal models.
“While the injection of vaccines and nose vaccines increase the level of antibodies in the blood of the mouse, only the nasal vaccine that allows the secretion of ribs to the lungs, where the respiratory virus needs a cottage to infect the host,” Iwasaki said.
If the nose vaccine proved safe and efficient in humans, Iwasaki imagined they were used together with the current vaccine and booster that worked throughout the system to add a reinforcement to the immune system to the source of infection.
The author’s first colleague is Ji Eun Oh, Eric song, and Miyu Moriyama, all from Yale.
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