South African captain Toba Bavuma crashed 72 Run and Bowler then limited Ireland because visitors won 49 to complete the net sweep of their three Twenty20 international matches in Belfast on Saturday.
South Africa won the opening in Dublin on Monday by 33 runs and sealed a 42-run victory in the second match three days later, also in Belfast.
Scoreecardperima, who won a throw and was chosen for bats, without key players Quinton de Kock, Lungi Ngidi and Tabraiz Shamsi, who were among the five players resting for the match.
Skipper Bavuma and Reeza Hendricks (69 Run) Installing the opening goal Partnership 127 to lead South Africa to a strong start before David Miller was wrapped in an unbeaten from 17 balls to set a mighty target in 190.
Ireland responded badly, Ireland was bad, losing Paul Stirling Opener (18) and Kevin O’Brien (2) in the first five overs before Skipper Andy Balbirnie tried to save the host.
But Balbirnie (27) was trapped by LBW by George Linde’s left arm spinner (2-21), while Weaian Mulder (2-10) and Lizaad Williams (2-30) (2-30) was also problematic Ireland as the host was destroyed under pressure and finished 140 for nine.